Indinavir: What It Is and How It Helps

If you or someone you know has been given Indinavir, you probably have a lot of questions. It’s a protease inhibitor used to treat HIV, and it works by stopping the virus from making new copies of itself. In plain language, think of it as a wrench that jams the virus’s factory line, keeping the infection from spreading.

How Indinavir Works

Indinavir targets an enzyme called HIV protease. This enzyme helps the virus cut large protein pieces into smaller, functional parts that the virus needs to assemble new particles. When Indinavir blocks protease, those pieces stay stuck together and the virus can’t finish building infectious units. The result is a slower viral load and a stronger immune system.

Because it attacks a specific step in the virus’s life cycle, Indinavir is often combined with other anti‑HIV drugs. That combo approach makes it harder for the virus to develop resistance. If you’re on a multi‑drug regimen, your doctor will explain how each pill fits into the bigger picture.

Taking Indinavir Safely

Timing matters. Indinavir should be taken on an empty stomach—usually one hour before or two hours after a meal. Food can drop the drug’s absorption, meaning you get less of it in your bloodstream. If you miss a dose, take it as soon as you remember, but skip it if it’s almost time for the next one. Double‑dosing isn’t safe.

Stay hydrated. Indinavir can cause kidney stones, and drinking plenty of water helps flush the kidneys. Aim for at least eight glasses a day, and talk to your doctor if you notice any pain when you pee or blood in your urine.

Watch for side effects. Common ones include nausea, fatigue, and a bitter taste. Some people get a rash or feel dizzy. If you experience severe stomach pain, dark urine, or sudden swelling, call your healthcare provider right away—those could be signs of more serious problems.

Keep your pharmacy in the loop. Inform them about any other meds, supplements, or over‑the‑counter drugs you take. Indinavir can interact with drugs like certain anti‑fungals, antibiotics, and even some cholesterol pills. A quick chat with the pharmacist can prevent unwanted interactions.

Regular check‑ups are key. Your doctor will monitor your viral load, CD4 count, and kidney function every few months. These labs tell you if the treatment is on track or if adjustments are needed.

Finally, don’t stop the medication on your own. Even if you feel better, quitting early can let the virus rebound and become harder to control. If you’re thinking about a break, discuss a tapering plan with your doctor.

Indinavir can be a powerful tool in the fight against HIV when used correctly. By following the dosing schedule, staying hydrated, and keeping an eye on side effects, you give yourself the best chance for a stable, healthy life.